Our development pipeline spans four organs. All organs use the same Base Unit.
Pancreas
NEED: Diabetes affects ~500 million people. It’s a global public health priority, due to the unsustainable demands it places on individuals, their carers, health systems & society. For Type 1 diabetics, a Pancreas transplant offers hope for a life free of insulin injections.
EVIDENCE: Grant-supported studies (>$10m) into the performance of Persufflation as a means of preserving pancreatic islets demonstrated 24h preservation, improved yields, and greater islet potency.
In Q4 2022 we are initiating evaluations across UK, Europe and the US with our prototype units. Going forward we intend to work closely with organisations such as Kugelmeiers whose technologies, combine with ours, have the potential to truly transform this field.
Kidney
NEED: Millions of people worldwide endure chronic dialysis as a result of kidney failure associated with End Stage Renal Disease (ESRD). Kidney transplants offers fewer co-morbidities and substantial health economic benefits as measured by Quality Adjusted Life Years.
EVIDENCE: There is significant published evidence backing the application of persufflation during kidney transplantation. Research has highlighted the potential for persufflation to resuscitate organs that have suffered from significant warm ischaemia.
Liver
NEED: Non-alcoholic fatty liver disease NAFLD is an emerging western pandemic will likely substantially increase demand for liver transplants.
EVIDENCE: Liver persufflation dates to the early 1980’s where benefit was shown even after prolonged ischaemic exposure. A large single-centre RCT was published in April 2019. It demonstrated both the safety of persufflation and the potential for persufflation to safely increase utilisation of livers which would have otherwise gone unused (e.g. from more elderly recipients).
Heart
NEED: Approximately 6 million Americans live with chronic heart failure. ~650,000 new patients are diagnosed with heart failure each year. ~250,000 of these could benefit from heart transplantation.
EVIDENCE: Studies have shown that PSF has the capacity to improve or maintain the metabolic quality and function of the heart. Bill Scott (ScubaTx CSO) has experience of evaluating the use of PSF in heart preservation as long ago as 2011.